Oxidative Stress: Eustress and Distress - Hot Topic will be highlighted by Prof. Helmut Sies
The physiological low exposure to oxidants (oxidative eustress) is essential in control of life processes through redox signaling and for maintenance of appropriate stress response capacity. H2O2 is a central redox signaling molecule, maintained at low nM overall concentration intracellularly.
Subcellular organelles (i.e. mitochondria, peroxisomes, endoplasmic reticulum, nucleus and the cytosol) operate at their particular setpoint level for H2O2 in redox signaling. The initial step in redox signaling is by reaction of H2O2 with susceptible protein cysteine thiolates to form the corresponding sulfenates, causing changes in protein properties. Subsequently, metabolic pathways are modulated. Stress response systems such as Nrf2 and NF-kB provide for adaptation, restoring redox balance.
Supraphysiological exposure to H2O2 (oxidative distress) leads to non-specific oxidation of biomolecules and to disruption of redox signaling, which can lead to excessive stress responses, inflammation, autophagy and cell death. Fundamental life processes as well as metabolic disorders, diseases and aging have an oxidative stress component, an active field for research for a future redox medicine.
Paris Redox 2020 Team
October 8-9, 2020 - Paris, France
www.isanh.net
