Paradoxical effects of ROS: Increasing tumorigenesis but improving response to some chemotherapies

F. Mechta-Grigoriou RedoxIn last years, different teams demonstrated that a chronic oxidative stress accelerates aging and increases metastatic spread, by deeply modifying tumour micro-environment. However, while oxidative stress increases tumour development, it can also improve response to chemotherapy in ovarian cancer patients, in particular to Taxanes. Moreover, autophagy, cellular process well-known to circumvent intracellular stresses, helps tumour cells from triple-negative breast cancer patients to escape from chemotherapy. Thus, oxidative stress promotes tumorigenesis but can, in the mean time, improve chemosensitivity, defining the paradoxical effect of Reactive Oxygen Species. 

During Paris Redox World Congress 2017, Dr Fatima Machta-Grigoriou from Institut Curie and INSERM,  France will present the pros and cons of intracellular oxidative stress and activation of downstream signalling pathways, such as MEK/ERK, with immediate translational applications for cancer patients.

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